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Cerebral Blood Flow Regulation $79.00
Authors: Nodar P. Mitagvaria ( Inst. of Physiology, Tbilisi, Georgia) Haim (James) I. Bicher (Valley Cancer Institute, Los Angeles, CA) 
Book Description:
Studies of the mechanisms relating blood supply to the brain appeared to be, in some sense, at a deadlock. Despite extensive application of different methodical approaches, no qualitative progress has been observed in these studies at the present time. This is perhaps due to the traditional, but not understandable, separation of neurophysiological and "circulatory" studies. It may seem very paradoxical, but the study of cerebral blood circulation proceeds almost in complete isolation from the knowledge about brain functions and does not take into account the specificity of the working brain as a part of the whole body. This book comprehensively addresses the issues of blood flow regulation.

It is well known that the brain belongs to the group of organs having a high level of oxygen consumption. Oxygen consumption by the brain is an average 4.6 ml per 100 g of tissue per minute. In humans, the level of oxygen consumption by the whole brain attains 46 ml/min. This makes up approximately 20% of the total oxygen volume consumed by the organism. Consequently, the cerebral tissue is characterized by highly energetic processes. There is evidence indicating that even in functionally resting conditions, 18% of the entire energy expenditure of the body is utilized by the brain Calculations made by Rushmer indicate that the intensity of energy consumption by the human brain appears to be on average 20 Watt.

Table of Contents:

SECTION 1. Regulation of local cerebral blood flow during systemic arterial pressure changes.

Chapter I. Some theoretical prerequisites
1.1. Historical background
1.2. Possible reasons for controversial interpretations of the results in the study of autoregulation.

Chapter II. Main theories of autoregulation of cerebral blood flow
2.1. Miogenic theory
2.2. Metabolic theory
2.3. Neurogenic theory

Chapter III. Analysis of dynamic characteristics of local cerebral blood flow autoregulation
3.1. Analysis of the dynamic characteristics of local CBF autoregulation in case of short-lasting systemic arterial pressure changes - Results of modelling
3.2. Dynamic characteristics of autoregulation of cerebral blood supply in response to prolonged variations in systemic arterial pressure

Chapter IV. Structural organisation in the brain blood supply autoregulation.

SECTION 2. Regulation of local cerebral blood flow during oxygen insufficiency

Chapter V. Some theoretical prerequisites
5.1. Historical background
5.2. The homeostatic range of cerebral blood flow and its role in heterogenity of CBF-responses during hypoxia

Chapter VI. Dynamic characteristics of regulation of local blood flow in the cerebral cortex under conditions of hypoxia, anoxia and asphyxia

SECTION 3. Regulation of local blood flow in the brain during changes in its functional-metabolic activity

Chapter VII. General problems of the brain functional activity and local blood flow coupling
7.1. Blood supply to the cortex of "nonworking" brain
7.2. The local blood flow coupling with cortical electrical activity
7.3. Blood flow in the cortex during sensory stimulation
7.4. Blood flow in the cortex during motor activity
7.5. Blood flow in the cortex during mental activity
7.6. Blood flow in the cortex during emotional actions

Chapter VIII. Dynamic characteristics of local blood flow regulation in different brain structures during performance of behavioral acts
8.1. Choice of the experimental conditions
8.2. Redistribution of local blood flow in different cortical areas during maze task solution.
8.3. Possible mechanisms of the cortical blood flow responses during functional loads
8.4. Dynamics of local blood flow in the rats cerebral cortex following injection of anticholinergic drugs.

Chapter IX. Dynamics of local blood flow and oxygen tension in the brain in different phases of the sleep-waking cycle
9.1. Historical background
9.2. Local blood flow and PO2 changes in the dorsal hippocampus and sensorimotor cortex during sleep-wakefulness cycle

SECTION 4. Cerebral blood flow, oxygen supply, and morphological changes induced by local hyperthermia

Chapter X. Dynamics of local cerebral blood flow during microwave radiation
10.1. Experimental and clinical study of microwave radiation
10.2. Dynamic characteristics of the regulation of local cerebral blood flow during local microwave radiation of the brain.

Chapter XI. Physiological and morphological changes in cerebral tissue, caused by hyperthermia-induced thrombosis of the cerebral vessels.
11.1. The physiological effects of hyperthermia treatment
11.2 The role of local blood flow intensity, blood rheological properties and free radicals in development of local hyperthermia-induced morphological changes in cerebral tissue



      Neurology - Laboratory and Clinical Research Developments
   Binding: ebook
   Pub. Date: 2009
   ISBN: 978-1-60741-405-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Cerebral Blood Flow Regulation