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The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology - 2008 update $265.00
Editors: Mario Di Napoli (SMDN, Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Italy) Cezary Wojcik (Indiana University School of Medicine, Indiana)
Book Description:
The ubiquitin-proteasome field has experienced a breathtaking development from obscure origins in the late 1970s and early 1980s, through a maturing but a well circumscribed field in the 1990s, into a huge, and ever growing interdisciplinary area in the 2000s. Nearly 7% of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system (UPS), making it the most complex of all biochemical pathways. This complexity depends mostly on its hierarchical organization, where the 20S proteasome is the common machinery mediating total or partial degradation of practically any protein in our body. Proteolysis via the UPS is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. Controlling where and when a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments.
The 24 articles of this updated collection describe the authors' research, from medical and academic research facilities worldwide, on various aspects of the UPS in nervous system. The articles discuss research of the UPS in connection with many important aspects of nervous system development, physiology and diseases, ranging from basic sciences to more specific topics useful for both basic neuroscientists and active clinical neurologists in an attempt to present in one place a cross-field, translational reference in a format accessible to a practicing neurologist as well as to a neuroscientist. Due to the inherent nature of the topic, the book has crossed over discipline barriers, engaging an amazing international team of specialists from disparate fields to conduct the readers across the principal avenues of the UPS physiology and pathology in the nervous system.

Table of Contents:
Chapter 1. INTRODUCTION
(Mario Di Napoli and Cezary Wójcik, Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Italy; Indiana University School of Medicine, IN. USA)pp.1-4

Chapter 2. MECHANISMS AND SUBSTRATE SPECIFICITY OF DESUMOYLATING ENZYMES (Miklós Békés and Guy S. Salvesen, Burnham Institute for Medical Research, La Jolla, CA. USA)pp.5-32

Chapter 3. CROSSTALK BETWEEN THE UBIQUITIN AND SUMO PATHWAYS (Huaiyu Sun and Tony Hunter, Salk Institute for Biological Studies, La Jolla, CA. USA)pp.33-52

Chapter 4. THE ROLES OF THE UBIQUITIN-PROTEASOME SYSTEM IN THE CONTROL OF CIRCADIAN CLOCKS (Qun He, Chi-Tai Tang and Yi Liu, College of Biological Sciences, China Agricultural University, China; University of Texas Southwestern Medical Center, TX. USA)pp.53-68

Chapter 5. ROLES OF THE UBIQUITIN PROTEASOME PATHWAY IN TRANSCRIPTIONAL REGULATION (Thomas G. Gillette, University of Texas Southwestern Medical Center, TX. USA) pp.69-80

Chapter 6. ROLE AND FUNCTION OF THE UBIQUITIN-PROTEASOME SYSTEM IN NEURAL STEM AND PROGENITOR CELLS (Cord Naujokat and Tomo Šarić, University of Heidelberg, Heidelberg, Germany; University of Cologne, Germany) pp.81-112

Chapter 7. UBIQUITIN/PROTEASOME SYSTEM IN MITOTIC AND MITOTIC-LIKE REGULATION DURING BRAIN DEVELOPMENT AND PATHOLOGY
(Jacek Z. Kubiak and Mark A. Smith, CNRS/University of Rennes 1 Rennes cedex, France; Case Western Reserve University, Cleveland, Ohio, USA)pp.113-130

Chapter 8. ROLE OF SYNAPSE-LOCALIZED E3 UBIQUITIN LIGASE IN REGULATING NEURAL TRANSMISSION (Ikuko Yao, Hiroshi Ageta, Mitsutoshi Setou (Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan; Hamamatsu University School of Medicine, Japan) pp.131-150

Chapter 9. REGULATION OF GABAA RECEPTOR SYNAPTIC EXPRESSION BY THE UBIQUITIN PROTEASOME SYSTEM (Richard S. Saliba and Stephen J. Moss, Tufts University, Boston, MA. USA; University College, London)pp.151-166

Chapter 10. ROLES OF THE UBIQUITIN PROTEASOME SYSTEM IN THE DEVELOPMENT AND FUNCTION OF THE NEUROMUSCULAR JUNCTION (Zhonghua Lu, Mary P. Heyer, and Guoping Feng, Duke University Medical Center, Durham, NC. USA) pp.167-180

Chapter 11. THE INTERRELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES (ROS) AND PROTEASOME INHIBITION AS INDUCERS OF NEURONAL CELL DEATH (Luena Papa and Patricia Rockwell, Hunter College of City University of New York, NY. USA)pp.181-208

Chapter 12. THE ROLE OF THE UBIQUITIN PROTEASOME SYSTEM IN PROINFLAMMATORY CYTOKINE SIGNALING IN THE CENTRAL NERVOUS SYSTEM (Kyungsun Choi, Jungsul Lee, and Chulhee Choi, KAIST Institute for the BioCentury, KAIST, Korea)pp.209-224

Chapter 13. ROLE OF IMMUNOPROTEASOMES IN AGEING AND NEURODEGENERATIVE DISEASES. Michele Mishto, Elena Bellavista, Melanie Dyllick-Brenzinger and et al., University of Bologna, Italy; Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity ‘L. Galvani’ (CIG), University of Bologna, via S. Giacomo 12, Bologna, 40126, Italy; Charité-Universitätsmedizin Berlin, Monbijoustr, Germany)pp.225-248

Chapter 14. GLIA, INFLAMMASOMES AND PROTEASOMES IN NEURODEGENERATIVE AND AUTOIMMUNE DISEASES (Bosede Adenekan and Maria E. Figueiredo-Pereira, Department of Biological Sciences, Hunter College of City University of New York, NY. USA)pp.249-270

Chapter 15. THE UBIQUITIN-PROTEASOME SYSTEM AND THE AGGRESOME-AUTOPHAGY PATHWAY: INTERSECTING MECHANISMS OF MISFOLDED PROTEIN CLEARANCE IN NEURODEGENERATIVE DISEASE. (James A. Olzmann, Lih-Shen Chin, and Lian Li, Emory University School of Medicine, Atlanta, GA USA, Stanford University, CA. USA)pp.271-302

Chapter 16. NOVEL FUNCTIONS OF PARKIN (Antoine Duquette and Edward A. Fon, Montreal Neurological Institute; McGill University, Quebec, Canada)pp.303-326

Chapter 17. VALIDITY OF TARGETING THE UBIQUITIN PROTEASOME SYSTEM IN THE ESTABLISHMENT OF NEW ANIMAL MODELS OF PARKINSON'S DISEASE (Anne M. Landau, Ĺrhus University Hospital, Denmark; University of British Columbia, Vancouver, Canada)pp.327-352

Chapter 18. THE INTERRELATIONSHIP BETWEEN AUTOPHAGY AND THE UBIQUITIN PROTEASOME SYSTEM IN ALS MODELS (Nobutoshi Morimoto and Koji Abe, Okayama University, Okayama, Japan)pp.353-370

Chapter 19. THE ROLE OF THE UBIQUITIN PROTEASOME SYSTEM IN THE PATHOGENESIS OF HUNTINGTON'S DISEASE AND OTHER POLYGLUTAMINE DISORDERS (Mathieu Lesort and Gail V.W. Johnson, University of Alabama at Birmingham, AL. USA; University of Rochester, Rochester, NY. USA)pp.371-396

Chapter 20. THE UBIQUITIN PROTESOME SYSTEM DYSFUNCTION AND PROTEIN AGGREGATION AFTER BRAIN ISCHEMIA (Bingren Hu and Chunli Liu, University of Miami Miller School of Medicine, Miami, FL. USA)pp.397-420

Chapter 21. TRANSIENT CEREBRAL ISCHEMIA TRIGGERS A DRAMATIC ACTIVATION OF SMALL UBIQUITIN-LIKE MODIFIER (SUMO) CONJUGATION – POSSIBLE SIGNIFICANCE (Wei Yang, Huaxin Sheng and Wulf Paschen, Duke University Medical Center, Durham, NC. USA)pp.421-440

Chapter 22. UBIQUITINATION, SUMOYLATION AND DE-SUMOYLATION OF HIF-1, A KEY MOLECULE INVOLVED IN BRAIN DEVELOPMENT AND ADAPTATION TO HYPOXIA IN ADULT BRAIN (Sui Zhang, Jinke Cheng, and Edward T.H. Yeh, University of Texas M.D. Anderson Cancer Center, Houston, TX. USA; Shanghai Jiaotong University, China)pp.441-468

Chapter 23. TUNING NODAL SIGNALING VIA THE UBIQUITIN-PROTEASOME SYSTEM (Yan Xiao and Chenzhong Kuang (Indiana University School of Medicine at Evansville, Evansville, IN. USA)pp.469-490

Chapter 24. THE ROLE OF UBIQUITIN PROTEASOME SYSTEM AND PROTEASOME INHIBITORS IN BRAIN TUMORS (Jan Styczynski, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland)pp.491-520

Index pp.521-552

   Series:
      Biochemistry Research Trends
   Binding: ebook
   Pub. Date: 2010
   ISBN: 978-1-61324-045-8
   Status: AV
  
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The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology - 2008 update