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An Overview of Genetic Factors and Environmental Triggers in the Pathogenesis of Tourette’s Syndrome $69.00
Authors: Cong-Yi Wang, Shi-Guo Liu, Ping Yang, Zhimin Miao, Qian Dong, Changgui Li and Wei Wang (Medical School Hospital of Qingdao University, Qingdao, P.R. China) 
Book Description:
Tourette’s syndrome (TS) is an inheritable, childhood-onset neuropsychiatric disorder characterized by the presence of motor and phonic tics. Despite decades of extensive studies, the exact disease etiology remains poorly understood. It is believed that susceptibility to TS is determined by the interactions of multiple genetic loci with unknown environmental factors. As a result, a great deal of research has been focused on identifying TS susceptibility genes. Thus far, at least 12 susceptibility loci have been suggested by genome-wide screenings, but none of them has been replicated probably due to genetic heterogeneity. Candidate gene approach has also suggested evidence for several genes relevant to neuronal signaling such as dopamine receptor and serotonin receptor. This book discusses the current state of genetic studies in TS susceptibility.

Table of Contents:
Introduction:

1. Clinical Characteristics of TS and its Impact on Quality of Life (QOL)

2. Genetic Factors for Tourette’s Syndrome

3. Update of Linkage/Association Studies

4. Progress for the Analysis of Chromosomal Abnormalities

5. Environmental Triggers in Tourette’s Syndrome

6. Food Chain and TS

7. Psychosocial Stress and TS

8. Changes for Life Style and TS

9. Challenges for Future Genetic Study of TS

10. Association versus Linkage: The Right Choice for Future Study

11. Candidate Genes versus Genome-Wide Approach

12. Summary and Remarks

Acknowledgements

Index

   Series:
      Neuroscience Research Progress
   Binding: ebook
   Pub. Date: 2010
   Pages: 5.5 x 8.5
   ISBN: 978-1-61728-254-6
   Status: AV
  
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An Overview of Genetic Factors and Environmental Triggers in the Pathogenesis of Tourette’s Syndrome