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Telomerase: Composition, Functions and Clinical Implications $95.00
Editors: Aiden N. Gagnon
Book Description:
Telomerase is a ribonucleoprotein enzyme that catalyzes the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential.
Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumor progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.

Table of Contents:

Telomerase beyond Telomeres: New Roles for an Old Enzyme
(Gabriele Saretzki, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE1, United Kingdom)

Telomerase and Telomeric Proteins: A Life beyond Telomeres
(Ilaria Chiodi, Cristina Belgiovine, Chiara Mondello, Istituto di Genetica Molecolare, CNR, Pavia, Italy)

Histone Deacetylase Inhibition as an Anticancer Telomerase-Targeting Strategy
(Ruman Rahman, Children’s Brain Tumour Research Centre, Medical School, University of Nottingham, United Kingdom)

Telomerase Role in Pituitary Adenomas
(A. Ortiz-Plata, Laboratory of Experimental Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico)

Regulations of Telomerase Activity and WRN Gene Expression
(Fumiaki Uchiumi, Yoshikazu Higami, Sei-ichi Tanuma, Tokyo University of Science, Chiba, Japan)

Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis
(Eiso Hiyama, Keiko Hiyama, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, and others)*


      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: ebook
   Pub. Date: 2010 - 3rd Quarter
   Pages: 6 x 9
   ISBN: 978-1-61728-339-0
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Telomerase: Composition, Functions and Clinical Implications