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Pluripotent Stem Cells $265.00
Editors: Derek W. Rosales and Quentin N. Mullen
Book Description:
Pluripotent cells of the early embryo originate all types of somatic cells and germ cells of adult organism. Pluripotent stems cell lines were derived from mammalian embryos and adult tissues using different techniques and from different sources. Despite different origin, all pluripotent stem cell lines demonstrate considerable similarity of the major biological properties. This book examines the fundamental mechanisms which regulate normal development of pluripotent cells into different lineages and are disrupted in cancer initiating cells. Analysis gene expression profiles, differentiation potentials and cell cycle of normal and mutant pluripotent stem cells provide new data to search molecular targets to eliminate malignant cells in tumors. In this book, the authors also aim to present a global picture of how extracellular signals, intracellular signal transduction pathways and transcriptional networks cooperate together to determine the cell fate of pluripotent stem cells. Practical, ethical and legal considerations that must be addressed before induced pluripotent stem (iPS) cells can realize their potential in the treatment of degenerative disease is discussed as well. Recent advancements in the cancer stem cell hypothesis are also summarized and the challenges associated with targeting resistant cancers in the context of stem cell microenvironments are presented.

Table of Contents:
Preface

Normal and Pathological Development of Pluripotent Stem Cells, pp. 1-45
(Olga F. Gordeeva, Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia)

Molecular Mechanism Involved in the Maintenance of Pluripotent Stem Cells, pp. 47-79 (Raymond Ching-Bong Wong, Peter J. Donovan, Alice Pebay, Department of Biological Chemistry, University of California Irvine, Irvine, CA, and others)

Generation of Clinically Relevant “Induced Pluripotent Stem” (iPS) Cells, pp. 81-112 (Corey Heffernan, Huseyin Sumer, Paul J. Verma, Reprogramming and Stem Cell Laboratory, Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia)

Amniotic Fluid and Placental Stem Cells, pp. 113-135
(Emily C. Moorefield, Dawn M. Delo, Paolo De Coppi, Anthony Atala, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC)

Exploring a Stem Cell Basis to Identify Novel Treatment for Human Malignancies, pp. 137-154
(Shyam A. Patel, Pranela Rameshwar, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ, and others)

Outstanding Questions Regarding Induced Pluripotent Stem (iPS) Cell Research, pp. 155-171
(Miguel A. Esteban, Jiekai Chen, Jiayin Yang, Feng Li, Wen Li, and Duanqing Pei, Chinese Academy of Sciences Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Guangzhou, China)

Lepidopteran Midgut Stem Cells in Culture: A New Tool for Cell Biology and Physiological Studies, pp. 173-184
(Gianluca Tettamanti, Morena Casartelli, Dipartimento di Biotecnologie e Scienze Molecolari, Università degli Studi dell’Insubria, Varese, Italia, and others)

Are Embryonic Stem Cells Really Needed for Regenerative Medicine?, pp. 185-190
(David T. Harris, Dept. Immunobiology, The University of Arizona, Tucson, AZ)

Genetic Stability of Murine Pluripotent and Somatic Hybrid Cells may be Affected by Conditions of their Cultivation, pp. 191-211
(Shramova Elena Ivanovna, Larionov Oleg Alekseevich, Khodarovich Yurii Mikhailovich, Zatsepina Olga Vladimirovna, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia)

Recent Advancements towards the Derivation of Immune-Compatible Patient-Specific Human Pluripotent Stem Cell Lines, pp. 213-226
(Micha Drukker, Institute for Stem Cell Biology and Regenerative Medicine, Stanford, CA)*

Pluripotent Cells in Embryogenesis and in Teratoma Formation, pp. 227-247
(O.F. Gordeeva, Institute of Developmental Biology Russian Academy Sciences, Moscow, Russia)*

Index

   Series:
      Stem Cells - Laboratory and Clinical Research
   Binding: ebook
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-61209-215-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
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