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DNA Adducts: Formation, Detection and Mutagenesis $265.00
Editors: Emerson Álvarez and Roberto Cunha
Book Description:
Numerous physical and chemical stress factors, endogenous or exogenous, challenge living organisms. Metabolization processes generate highly reactive intermediates which can covalently bind to DNA, resulting in bulky addition products called "adducts." DNA adduct formation appears to be a general response of plants to organic chemical exposure, whether in controlled conditions or in the field. In particular, common carcinogenic pollutants and pesticides promote the formation of DNA adducts in plants. The authors of this book examine the development of DNA adducts, as well as the ways in which they can be eliminated due to DNA repair pathways. In this book, the data from in vivo transgenic assays is also examined, which can help to clarify specific pre-mutagenic adducts, DNA repair functions and mutational events that may be involved in the mutagenicity of human carcinogens. Other chapters in this book identify and discuss novel anthracyclines capable of forming DNA adducts, the role of DNA adducts as early biomarkers in the screening and development of marine anticancer drugs, the genotoxicity, such as DNA adduct formation, of air pollutants and its assessment by in vivo mutagenesis and a discussion of oxidative DNA damage, which can play an important role in the carcinogenic processes of PAHs and aromatic amines, in addition to bulky-DNA adducts formation.

Table of Contents:

Tidying Up a Molecular Catastrophe: In Vitro and In Vivo Repair of Unique DNA-Protein Cross Links pp.1-38
(David J. Baker, Arthur D. Riggs, Timothy R. O’Connor, Biology Department, Beckman Research Institute, Duarte, CA)

In Vivo Mutagenic Effects of Alkylating Agents Eliciting Different DNA-Adducts pp.39-60
(Henriqueta Louro, Maria João Silva, Department of Genetics, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal)

DNA Adduct Formation and Genotoxicity Assessment in Plants pp.61-82
(Frédérique Weber-Lotfi, Pierre Guillemaut, Benoît Rether, André Dietrich, Institut de Biologie Moléculaire des Plantes, CNRS/Université de Strasbourg, France and others)

Diet, Life-Style Habits and Malondialdehyde–Deoxyguanosine Adducts in a Group of Subjects Resident in the Rayong Province, Thailand.pp.83-102
(M. Peluso, P. Srivatanakul, A. Munnia, M. Ceppi, A. Jedpiyawongse, S. Sangrajrang, S. Piro, P. Boffetta, Cancer Prevention and Research Institute, Florence, Italy, and others)

Drug-DNA Adducts Formed by Formaldehyde Activation of Anthracycline and Related Anti-Cancer Agents pp.103-126
(Don R Phillips, Lonnie Swift, Kate Coldwell, Damian Spencer, Rebecca Bilardi, Benny Evison, Oula Mansour, Abraham Nudelman, Ada Rephaeli, Tad H Koch, Suzanne M Cutts, Department of Biochemistry, La Trobe University, Australia, and others)

Differential Modulation of Benzo[a]pyrene-Derived DNA Adducts in MCF-7 Cells by Marine Compounds pp.127-142
(Jamal M. Arif, King Faisal Specialist Hospital and Research Institute, Mohammed Kunhi, Yunus M. Siddiqui, Khalid A. El Sayed, Khaled Y. Orabi, Amal Al-Hazzani, Mohammed N. Al-Ahdal, Fahad M. Al-Khodairy)

Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis pp.143-154
(Yasunobu Aoki, Akiko H. Hashimoto, Hiromi Sato* and Michi Matsumoto
National Institute for Environmental Studies, Research Center for Environmental Risk, Onogawa, Tsukuba, Ibaraki, Japan)

GSTM1 and XRCC3 Polymorphisms: Effects on the Levels of Aflatoxin B1-DNA Adducts pp.155-168
(Xi-Dai Long, Yun Ma, Jin-Gang Yao, Fu-Zhi Ban, Yuan-Feng Zhou, Zhong-Hui Lin, Hong-Dong Huang, He-Ping Yang, Department of Pathology, Youjiang Medical College for Nationalities, Baise, Guangxi Zhuang Autonomous Region, China, and others)

Oxidative DNA damage and DNA adduct induced by polycyclic aromatic hydrocarbons and aromatic amines pp.169-180
(Shosuke Kawanishi and Shiho Ohnishi, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Japan)

Usefulness of Bulky DNA Adduct Formation as a Biological Marker of Exposure to Airborne Particulate Matter (Pm2.5) in In Vitro Cell Lung Models: A Comparative Study pp.181-212
(Sylvain Billet, Véronique Andre, Imane Abbas, Jeremie Le Goff , Anthony Verdin, François Sichel, Pirouz Shirali, Guillaume Garçon, Toxicologie Industrielle et Environnementale, Université du Littoral - Côte d’Opale, Maison de la Recherche en Environnement Industriel de Dunkerque, France, and others)

Index pp.213-232

      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: ebook
   Pub. Date: 2010
   Pages: pp.232
   ISBN: 978-1-61324-344-2
   Status: AV
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AN Announcing
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DNA Adducts: Formation, Detection and Mutagenesis