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Thrombin: Function and Pathophysiology
Retail Price: $170.00
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Editors: Thomas Stief (Institute of Laboratory Medicine and Pathobiochemistry University Hospital, Marburg, Germany)
Book Description:
Thrombin is the main factor of mammalian blood coagulation, a complex system generating fibrin clots that physiologically prevents critical bleeding at local areas of tissue injury. There are many diseases, situations, or drugs that critically alter the blood matrix. Then, thrombin is massively generated in the systemic circulation. The individual reader of the present book will understand a bit more the complicated thrombin generating system - called coagulation. Understanding thrombin means understanding coagulation. (Imprint: Nova Biomedical)

Please click on a chapter below to purchase separately

Chapter 0 - Preface: Thrombin – applied clinical biochemistry of the main factor of coagulation
Authors / Editors: (Thomas W. Stief)
***Open Access Chapter. Free Download Available***

Chapter 1 - Systemic thrombin in sepsis pp. 1-12
Authors / Editors: (Thomas W. Stief, Korinna Ulbricht, Martin Max)

Chapter 2 - Systemic thrombin, trypsin, or plasmin pp. 13-22
Authors / Editors: (Thomas W. Stief)

Chapter 3 - Glucose provokes pathologic plasmatic thrombin generation pp. 23-36
Authors / Editors: (Thomas W. Stief, Morad Mohrez)

Chapter 4 - The maximal plasma concentration of (delta-) negatively charged contact triggers influences plasmatic thrombin generation pp. 37-46
Authors / Editors: (Thomas W. Stief)

Chapter 5 - Thrombin generation by therapeutic immunoglobulins pp. 47-58
Authors / Editors: (Thomas W. Stief)

Chapter 6 - Thrombin generation by ethosuximide pp. 59-64
Authors / Editors: (Thomas W. Stief)

Chapter 7 - Thrombin generation by folic acid pp. 65-72
Authors / Editors: (Thomas W. Stief)

Chapter 8 - Thrombin generation by diclofenac pp. 73-84
Authors / Editors: (Thomas W. Stief)

Chapter 9 - Diagnostic ultrasound generates plasmatic thrombin pp. 85-112
Authors / Editors: (Thomas W. Stief, Volker Klingmüller, Eva Maria Müller-Stüler)

Chapter 10 - The diagnostic ultrasound – induced thrombin generation (37°C) is prevented by low molecular weight heparin pp. 113-130
Authors / Editors: (Thomas W. Stief, Volker Klingmüller)

Chapter 11 - Diagnostic ultrasound augments intrinsic coagulation activity pp. 131-148
Authors / Editors: (Thomas W. Stief, Volker Klingmüller)

Chapter 12 - Ultrasound phospholipid - microbubble contrast media generate thrombin pp. 149-158
Authors / Editors: (Thomas W. Stief, Volker Klingmüller)

Chapter 13 - Impaired thrombin formation in experimental acquired coagulopathies can be corrected by the administration of a prothrombin complex concentrate pp. 159-184
Authors / Editors: (Gerhard Dickneite, Ingo Pragst)
***Open Access Chapter. Free Download Available***

Chapter 14 - Historic perspectives in the development of thrombin inhibitors and their design as anthithrombotic drugs pp. 185-198
Authors / Editors: (Fritz Markwardt)

Chapter 15 - Emerging tasks of thrombin and its receptors in epithelial tumor development pp. 199-214
Authors / Editors: (Beatrice Uziely, Myriam Maoz, Zaidoun Salah, Mohammad Jaber, Hagit Turm, Sorina Grisaru-Granovsky, Rachel Bar-Shavit)

Chapter 16 - Thrombin transduction mechanisms mediating thrombin effects on vascular endothelium pp. 215-234
Authors / Editors: (Haraldur Halldorsson, Brynhildur Thors, Gudmundur Thorgeirsson)

Chapter 17 - Thrombin and vagal dysfunction in inflammatory bowel disease pp. 235-246
Authors / Editors: (Danielle M. Fritze, Michael W. Mulholland, Weizhen Zhang)

Chapter 18 - Thrombin mediated regulation of gap junctional intercellular communication and physical cell-cell coupling pp. 247-254
Authors / Editors: (Susan M. Baker, Matthias M. Falk)

Chapter 19 - Maternal decidual cell-generated thrombin in abruption and preeclampsia pp. 255-262
Authors / Editors: (Christina S. Han, Graciela Krikun, Frederick Schatz, Charles J. Lockwood)

Chapter 20 - Fibrinogen and Fibrin: structure and functional aspects pp. 263-292
Authors / Editors: (Rita Marchi Cappelletti)
***Open Access Chapter. Free Download Available***

      Recent Advances in Hematology Research
      Physiology - Laboratory and Clinical Research
   Binding: Hardcover
   Pub. Date: 2012
   Pages: 7 x 10 (NBC - C) 306pp.
   ISBN: 978-1-61942-087-8
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Thrombin: Function and Pathophysiology