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Ataxia: Causes, Symptoms and Treatment
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Editors: SungHoi Hong (College of Health Science, Korea University, Korea)
Book Description:
Ataxia is a neurological sign and symptom characterized by lack of coordination of muscle movement that is due to dysfunction of the parts of the nervous system, such as motor control of the cerebellum. Although the cause of the dysfunction varies from mutations in channels for potassium and/or calcium to progressive degeneration of cerebellar tissue-specific neurons, the neurological signs and symptoms of ataxia are similar. The treatment of ataxia and its effectiveness depend on the underlying cause, and it could be managed by pharmacological treatments and through physical therapy and occupational therapy. The treatment may ameliorate the signs of ataxia, but it is not likely to eliminate them entirely. In this book, the authors present current research in the study of the causes, symptoms and treatments on ataxia. (Imprint: Nova Biomedical)

Table of Contents:

1. Role of the ataxia telangiectasia mutated protein in stress-induced premature senescence;pp 1-27
(Razmik Mirzayans and David Murray, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada)

2. Ataxia teleangiectasia: molecular basis, diagnosis and treatment;pp. 29-45
(T. Broccoletti, G. Aloj, G. Giardino and C. Pignata, Department of Pediatrics, “Federico II” University, Naples, Italy)

3. The Neurobiology of episodic ataxia type-1, a shaker-like K+ channel disorder;pp. 47-75
(Pressia Mauro, D’Adamo Maria Cristina, Imbrici Paola, Section of human physiology, University of Perugia school of medicine, Perugia, Italy)

4. Mitochondrial ataxias;pp. 77-101
(Michelangelo Mancuso, Daniele Orsucci, Gabriele Siciliano, Department of Neuroscience, Neurological Clinic, University of Pisa, Italy)

5. Epidemic seasonal ataxic syndrome : epidemiology, clinical presentation, etiological mechanisms and therapy;pp. 103-108
(Bola Adamolekun, Department of Neurology,University of Tennessee Health Science Center, Memphis, TN, USA)

6. Clinical and genetic aspects of recessive ataxias;pp. 109-122
(Anne Noreau, Guy A. Rouleau and Nicolas Dupré, Centre of Excellence in Neurosciences of Université de Montréal (CENUM), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada and others)

7. Genetics at different levels in machado-joseph disease(MJD/SCA3): cause, modifiers and therapy;pp. 123-138
(Conceição Bettencourt, Manuela Lima, Institute for Molecular and Cell Biology (IBMC), University of Porto, Porto, Portugal and others)

8. Neuroimaging in spinocerebellar ataxia type 3 : clinical and anatomical correlates;pp. 139-148
(Anelyssa D’Abreu, Fernando Cendes and Iscia Lopes-Cendes, Department of Neurology, Department of Medical Genetics; Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, BRAZIL)

9. Computational analysis of ataxin proteins: new insight into their functional performance and ataxia development;pp. 149-165
(E. Pirogova, V. Vojisavljevic, J. L. Hernández Cáceres, I. Cosic, School of Electrical and Computer Engineering, RMIT University, Melbourne 3001, Victoria, Australia)

10. The pcd hamster: a new model of spinocerebellar ataxia with potential application for drug evaluation;pp. 167-176
(Kenji Akita and Hitomi Ohta, Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc., Fujisaki, Naka-ku, Okayama, Japan)

11. Stem cell replacement therapy as a potential treament for SCA1 disease;pp. 177-188
(Sunghoi Hong and Seongman Kang, Department of Biomedical Science, College of Health Science, Korea University, Jeongneung-dong, Seongbuk-gu; Graduate School of Biotechnology, Korea University, Anam-dong, Seoul, South Korea)


      Neuroscience Research Progress
      Neuroanatomy Research at the Leading Edge
   Binding: Hardcover
   Pub. Date: 2012 2nd Quarter
   Pages: 7 x 10 (NBC - C) 199pp.
   ISBN: 978-1-61942-867-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Ataxia: Causes, Symptoms and Treatment