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01.Inorganic Biochemistry: Research Progress
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Biomedical Applications of Lanthanum
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Authors: Harriet Nilsson, Anca Dragomir (University of Uppsala, Uppsala, Sweden),Godfried M. Roomans(University of Orebro.Orebro,Sweden 
Book Description:
Lanthanum has been used as a tracer to study tight junctions in epithelia by transmission electron microscopy. The key function of the tight junction complex (TJC) is to limit the paracellular permeability by forming a selectively permeable barrier between the apical and basolateral compartment of the extracellular space. Impaired regulation of the TJC causes a variety of diseases, such as autoimmune diseases, cancer development, infections, allergies and asthma. The advantage of lanthanum as an opaque probe is its small ionic radius (0.11 nm), compared to alternative methods, such as radioactive isotope techniques using extracellular tracers and light microscopy techniques with larger polar molecules. This book presents a variety of biomedical applications of lanthanum.
(Imprint: Nova Biomedical)

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Table of Contents:
1. Lanthanum as a tracer for the study of tight junctions;pp. 1-2

2. Structure and function of tight junctions;pp. 3-4

3. Methods to study the permeability of tight junctions in cell cultures;pp. 5-9

4. Lanthanum in the study of tight junctions in different tissues;pp. 11-22

5. Lanthanum as an inhibitor of ion channels;pp. 23-26

6. Uptake of lanthanum salts in the body;pp. 27-28

7. Lanthanum carbonate in the treatment of hyperphosphatemia in end stage renal disease;pp. 29-33


      Biomedical Devices and their Applications
   Binding: Softcover
   Pub. Date: 2010
   Pages: 6 x 9 (NBC - C), 61 pp.
   ISBN: 978-1-61728-906-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Biomedical Applications of Lanthanum