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01.Hematopoietic Stem Cells: Potential New Applications for Translational Medicine
02.Characterization of Human Adipose-Derived Stem Cells Cultured in Autologous Serum after Subsequent Passaging and Long Term Cryopreservation
03.Extramedullary Hematopoiesis Leading to the Production of a Novel Antigen-Presenting Cell Type in Murine Spleen
04.Genetically Engineered Blood Pharming: Generation of HLA-Universal Platelets Derived from CD34+ Progenitor Cells
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Extramedullary Hematopoiesis Leading to the Production of a Novel Antigen-Presenting Cell Type in Murine Spleen $45.00
Authors:  Rebecca A. Hinton and Helen C. O’Neill
Abstract:
The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis. 


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Extramedullary Hematopoiesis Leading to the Production of a Novel Antigen-Presenting Cell Type in Murine Spleen